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Article Collections

Breast cancer prognostic classification in the molecular era: the role of histological grade

Russo and James A. Cubitt , Joel G. Turner , Junmin Zhou , Alan F. List , David A. Sallman , Jana L. Dawson , Daniel M.

Molecular Staging of Node Negative Patients with Colorectal Cancer

Sullivan , Julio Chavez , Bijal D. Shah and Jeffrey E.

  • American Association for Cancer Research (AACR);
  • Accusing the American Judicial System of Rampant Corruption.
  • A Year of Travel Blogs 2010 in Words and Pictures.

Mayer , Christina E. Lorrey , Pakawat Chongsathidkiet , Karolina I. Woroniecka , Xiuyu Cui , Steven H. Identification of hypermutation and defective mismatch repair in ctDNA from metastatic prostate cancer. Elie Ritch , Simon Y. Chi and Alexander W. Figlin , Brian I. Clinical Trials: Immunotherapy. Mariana Ferreira Leal , Ben P. Cheang , Ian E. Elizabeth R. Gerstner , Kyrre E. Beers , Jorg Dietrich , Scott R. Plotkin , Ciprian Catana , Jacob M. Hooker , Dan G. Jain and Tracy Batchelor.

November 18, Translational Cancer Mechanisms and Therapy.

Cancer Is Still Beating Us—We Need a New Start

Ellsworth , Shruti Jolly , Andrew L. Carroll , William E. Evans and Jun J. Exploitation of CD for the targeted imaging of lethal prostate cancer. Nelson , Scott M. Dehm and Aaron M. Curtis W. McCloskey , David P. Cook , Brendan S. Kelly , Feryel Azzi , Christian H. Rayner , Douglas A. Gray , Robert W. Senterman and Barbara C. Pavlick , Rene Gonzalez , Karl D. Lewis , Omid Hamid , Thomas F. November 12, Precision Medicine and Imaging.

Simon Laban , Dominik S. Broglie , Christel C. Kestler , Cornelia Brunner , Patrick J. Schuler , Marlene C. Alexander M. Frankell and Elizabeth C. Youngtae Jeong , Jessica A. Hellyer , Henning Stehr , Ngoc T. Padda , Kavitha Ramchandran , Joel W. Neal , Heather Wakelee and Maximilian Diehn. Jenny L. Smith , Rhonda E. Farrar , Timothy J. Learn More About the AACR's Journals: Blood Cancer Discovery will provide a critical outlet for high-impact basic, translational, and clinical research on all disease subtypes of leukemia, lymphoma, myeloma, and associated diseases.


Studies published in Blood Cancer Discovery will describe mechanisms underlying disease biology; diagnostic and therapeutic development; and translation of these data into clinical trials. Cancer Discovery publishes high-impact articles featuring major advances in research and clinical trials. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic to epidemiologic studies. The journal also publishes News and Research Watch sections. Cancer Immunology Research publishes outstanding original articles reporting major advances in cancer immunology that span the discipline from basic investigations in host-tumor interactions to developmental therapeutics in model systems, early translational studies in patients, and late-stage clinical trials.

Cancer Prevention Research publishes articles that focus on cancer prevention, preclinical, clinical, and translational research, with special attention given to molecular discoveries and an emphasis on building a translational bridge between the basic and clinical sciences. A higher percentage of women were diagnosed with BC at later stages. There is a need for educating women about BC, self-examination of breast, and screening programs for early detection of BC. Background: Breast cancer BC is the most common cause of cancer-related mortality among women.

Despite recent advances in diagnosis and prognosis of breast carcinomas, noninvasive biomarkers have been poorly identified.

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  • Breast Cancer: Types of Treatment.

We evaluated the biomarker potential of miR and miR in tissue and plasma specimens of Iranian Azeri patients. Materials and Methods: Tumor specimens, paired nontumoral adjacent tissues, and matched plasma samples were collected from a number of thirty Iranian Azeri women with breast carcinoma.

Plasma of healthy women was used as the control. The relative expression of miR and miR was measured by real-time polymerase chain reaction. Furthermore, receiver operating characteristic ROC curve analysis of samples showed the area under the ROC curve of 0. Conclusion: Our data showed that miR and miR oncomiRs can be considered as noninvasive biomarkers for monitoring breast carcinomas. However, further investigations are needed to confirm the use of these noncoding RNAs in pathology.

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Background: Zamzam water ZW is a natural alkaline water that contains several minerals that may represent a powerful tool for cancer therapy. Objectives: In this research, in vitro antiproliferative and apoptotic effects of ZW were investigated in the human breast cancer cell line MCF Materials and Methods: This study was conducted between January and February The effects of ZW on the morphology and the cell viability of human breast cancer cell line MCF-7 were determined.

The cell death type and cell cycle changes were investigated using flow cytometry. Finally, reactive oxygen species ROS were also measured by fluorometric technique. The cell death occurred through the apoptosis pathway under both treatment conditions. Conclusion: All the results in the present study indicated, for the first time, that ZW might have anticancer and apoptotic effects on breast cancer cell line.

Aim of the Study: Both apoptotic induction and cell cycle blockade in cancer cells are effective strategies to eliminate cancer cells.

Many conventional cancer drugs that induce apoptosis and inhibit cell cycle progression have been reported as potential therapeutics for various types of cancer. Britannin is a natural sesquiterpene lactone that its profound anticancer properties were revealed in our previous study. In this study, we evaluated the effects of britannin on the cell cycle distribution and also cell cycle-related proteins. Materials and Methods: Analysis of cell cycle distribution was carried out using flow cytometer.

Results: The obtained results show that britannin at the low concentrations induces cell growth inhibition mainly through G1-phase arrest while it seems that apoptosis contributes to cell growth inhibitory effect of high doses of britannin. Reduction of cyclin D1 and CDK4 protein levels were also observed after treating cancer cells with britannin. Objective: The aim was to evaluate the parameters that influence the incidental presence of whole liver detected by simulation computed tomography simCT while irradiation in breast cancer patients and to evaluate the factors predicting the presence of the liver in simCT scanning and defining the inferior border in simCT.

During the evaluation, whether the entire liver was included in the simCT scanning and the level of the vertebra where the inferior border of the simCT scan passed were investigated. Left L and right R lung, L and R breast, and heart volume were recorded so that they would reflect the internal volume of the thorax.

From the simCT images, anteroposterior A-P distance at the jugular notch level, A-P and R-L lateral distances at manubriosternal joint alignment, A-P and R-L lateral distances at xiphisternal joint alignment were measured.